PEDS200 Lecture : Hormones

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Hormone basics secretion and removal y stimulation is from neural response (ex. Stimulation of epinephrine/norepinephrine from adrenal medulla), other hormones (ex. Insulin: increase in glucose and amino acid uptake; increase in synthesis of fat y glucagon: increase in glucose release from liver; increase in breakdown of fat. Anabolic ( build-up ) examples y testosterone: increase protein synthesis y gh: increase in cell growth and protein synthesis. Catabolic (breakdown) examples y cortisol and to a lesser extent glucagon: increase protein breakdown and increase in production of glucose. General hormone mechanism of action y induce secretory activity y ex. Exercise can increase thyrotropin (tsh) releasing factor produced by hypothalamus that acts on anterior pituitary to produce thyrotropin which stimulates the secretion of thyroxin from thyroid: increase metabolic rate, hr, etc. Exercise can increase epinephrine and initiate a second messenger system (ex. Cyclic amp system) that increases the breakdown of muscle glycogen among other things. y the cyclic amp mechanism of hormone action.

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