PHYSL212 Lecture Notes - Lecture 33: Protein Kinase, Stroke Volume, Afterload

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Physl 212 - lecture #33 - assessment of ventricular performance. Pressure volume loop: measures changes in the lv volume and pressure ***** know it: counter clockwise, phases. Filling phase of diastole occurs: stroke volume and work go in the same direction. Preload and afterload: preload: load ventricle faces before it begins to contract (i. e. edv, afterload: load ventricle faces after it begins to contract (i. e. , systolic pressure, systolic wall stress) Preload-dependence of stroke volume stroke volume ventricular performance from the ventricles! Frank-starling law of the heart: for end diastolic volume, you get a certain. More blood can get out from the heart: preload or end diastolic volume = , preload = stretch sarcomeres in ventricles = force of contraction = stroke volume. The concept of contractility: contractility is the heart what horsepower is to an automobile engine, increasing contractility increases performance but also decreases efficiency. Uses a lot of energy (atp, oxygen: [ca2+]in*** - defines contractility.

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