PHYSL210A Lecture Notes - Lecture 2: Complete Protein, Transcription Factor, Gene Expression
15 Sep 2018
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Translation: new protein starting to form as trna attach to mrna, inhibition of protein synthesis midway. Signal recognition protein binds the unfinished protein: signal recognition protein binds protein and ribosome complex to the rer, synthesis resumes, the signal sequence is cleaved, and synthesis continues, attachment of carbohydrate chains- glycosylation, complete protein. Ribosome dissociates: further post translational modification in the golgi apparatus. Castor bean: has component that impairs ribosomal function. Some antibiotics work against bacteria by blocking protein synthesis. The initiation of transcription is controlled because of cell differentiation: every cell in the body has specific functions so all cells do not have to activate the same genes. Transcription factor: proteins that regulate gene expression: activator, repressor. Tf binds to regulatory element to activate/ deactivate the transcription initiation site. When activated rna pol ii can bind to the transcription initiation site. Vascular endothelial growth factor (vegf) more blood vessels. Glycolytic enzymes generates atp from non-oxidative sources.
