PHYSL405 Lecture 10: 10
7 Nov 2016
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Document Summary
Interference with shh signaling causes defects in rpe development in embryonic chick eye. Hedgehog signaling from the ventral diencephalon regulates: separation of the eye field, optic stalk formation = later step after vesicle, ventral rpe patterning. The neural retina contains seven major cell classes derived from the neuroepithelium. Cells of each class are born in discrete intervals. Horizontal cells = first to differentiate (no sense) Rgc = need input (does not follow chronological order in which visual info is processed) = no sense. Last to form = bipolar cells and muller cells (housekeeper): bizarre b/c so important. Expression of markers as a function of different ages. Two phases of histogenesis in the rat retina. Rgcs, cones, hc, and amacrine cells = generated in phase 1. Amacrine, rods, bipolar cells and muller glia are generated in phase 2. Many more cells are generated in phase 2.
