PMCOL305 Lecture Notes - Lecture 8: Cyp2E1, Acetaldehyde, Alcohol Dehydrogenase
11 Oct 2016
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Clear link b/w chronic consumption and cancer of upper gastrointestinal tract, liver, colorectum and female breast tissue. In men, it may be as high as 10% In the upper gi, 50% of all cancers (both sexes) linked to alcohol consumption. Main culprits are acetaldehyde and reactive oxygen species. While most of this data typically comes from heavy drinkers (>4 drinks/day) new data shows there is no safe threshold for some cancers. There may be no safe level of ethanol consumption for some types of cancers. At 0, relati(cid:448)el(cid:455) risk = risk of (cid:862)(cid:374)or(cid:373)al(cid:863) (cid:374)o(cid:374)-drinkers. Causes chromosomal abnormalities (left): right = another version of middle (focus, as this is the primary product of acetaldehyde and dna (chart): control = no metabolic enzymes introduced. Ethanol added (measuring presence of middle of a); ie if alcohol around = dna mods seen. 4mp = inhibits enzyme (alcohol dehydrogenase) decrease in dna mod. Ethanol is metabolized to acetaldehyde by microbes in the saliva.
