PMCOL305 Lecture Notes - Lecture 4: Radioactive Tracer, Orbitofrontal Cortex, Autoreceptor
11 Oct 2016
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Document Summary
Learn importance of presynaptic dopamine receptors in mediating sensitivity to drugs of abuse. Understand that dopamine may be involved in reward and anticipation of reward. Learn how drug use changes glutamate levels and glutamate release. Learn how the presence of both glutamate and dopamine can trigger changes in gene expression. Da r have specific distribute on in diff parts of brain. Need da r; otherwise, da projections = no effect. D2 rs play a role in addiction issues. Used radioactively labelled drug in brain; allows where trace is binding in brain; color code density of r. Born this way or overuse leading to depletion of da. The number of da rs may play a role in drug-taking behaviours. D2r distribution by changing the rank troop; ie if take an alpha male and put in a pen with larger monkeys brain changes that lead to lower r level (social standing may affect da r distribution)
