PMCOL305 Lecture Notes - Lecture 19: Tachycardia, Alpha-Pyrrolidinopentiophenone, Ic50
Document Summary
Discuss why synthetic cathinones appeared on the market. Describe the structure and activity of the synthetic cathinones. Discuss experiments currently ongoing that are classifying mode of action of cathinones. Bath salts are a family of designer stimulant drugs that have become popular alternatives to (cid:862)traditio(cid:374)al(cid:863) drugs su(cid:272)h as (cid:272)o(cid:272)ai(cid:374)e a(cid:374)d mdma. Types in circulation frequently change over time as one type becomes illegal, new types emerge to avoid being illegal. Most have a reputation for being dangerous drugs that can harm or kill the user. Since 2010, at least 100 deaths assoc with mdpv use alone. Interesting ses a contaminant of a designer opioid drug caused parkinsonism in its users now used as investigative tool to induce parkinsonism in animal models. Often legality of drugs = based on their specific chemical structure. Therefore, if structure is changed sufficiently, it may no longer be illegal. Cathinone is a naturally occurring drug found in the plant khat formed groundwork for rest.