PMCOL305 Lecture Notes - Lecture 21: Opioid Overdose, Opioid Antagonist, Adenylyl Cyclase

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To describe the mech by which opioids act. Is an urban myth that everyone who tries opioids addicted. Many users are chippers occasional use proves ppl do not become instantly addicted. Also ha(cid:448)e (cid:862)(cid:374)eedle freaks(cid:863) (cid:449)ho asso(cid:272) iv i(cid:374)je(cid:272)t (cid:449)ith the drug a(cid:374)d start to e(cid:374)joy the act of. True addicts use minimum once daily, can be 20 or more times a day. We have endogenous opioid-like substances (we make peptide-based analogues of opioids): made up of a small number of aas and can modulate neurotransmission. 4 distinct families (rs): usually released upon acute stress. Enkephalins (delta), endorphins (mu), endomorphins (mu), and dynorphins (kappa) Each family is derived from diff precursor (larger) proteins. Parts of morphine mimic the tyrosine an amine group separated from a phenol ring by 2 carbons. Involved in pain, placebo responses, acute stress responses, social attachment. Morphine etc can bind to opioid rs b/c have similar structures.

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