REN R360 Lecture Notes - Isotopes Of Iron, Nuclear Power Plant, Acute Radiation Syndrome
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Health effects from exposure to radionuclides
There are 2 different kinds of health effects.
1) Stochastic effect – Humans exposed to long term, lower level of radiation. This is most
problematic because it is very hard to detect and to know what will happen to our health
after long time exposure to lower level of radiation. Hard to detect and not 100% known.
What is known is that if the amount of radiation increases the severity of this affect will
not change and will stay the same and the type of illnesses will be the same. But the risk
to get that illness will increase. Risk of getting cancer will be higher. This amount of
radiation is proven to cause cancer. 2 effects associated with this Stochastic:
Cancer is uncontrolled growth of cells (any kinds of cells as there are many kinds of
cancers). Naturally in our physiological functions, our cells divide and produce new ones
to replace old ones. This natural physiological process is controlled by our genetic
material. But if certain radiation disrupts this natural process, it will cause cancer.
Basically, cells keep on growing without reason. And this reason is radio nuclides.
Another effect that can be caused is changes in DNA (changes to genetic material).
Two problems can happen because of this. One is Teratogenic changes and another is
genetic changes (mutations). What are teratogenic effects: birth defects. Mother is
exposed for long term to lower level of radiation (most sensitive in 8- 15 week of
pregnancy) ; her unborn child will have some problems like smaller head or brain size,
poorly formed eyes, mental retardation. Genetic mutations are changes that can be
transferred from the parent to the child. Teratogenic changes cannot be transferred to the
child, but the offspring is affected anyways, which we see when child is born.
2) Non-Stochastic effect – These are acute effects. These effects are seen in humans that
are exposed to very high levels of radiation for a short period of time. These effects are
also very visible and obvious. These effects, if level of radiation increases, will get more
severe. We know this based on cases of many different nuclear accidents everywhere
(Chernobyl, Hiroshima Nagasaki, workers that are exposed to very high level of radiation
Some literature says that these effects can cause cancer, but some literature disagrees
that it causes cancer. Based on Epidemiological studies and other examples, it seems that
yes these effects can cause cancer, because most data shows increased number of
different types of cancer in areas such as Chernobyl or where we saw some accidents.
What we know for sure is that this high level of radiation causes radiation sickness
(nausea, weakness, hair loss, skin burn or diminishing organ function, premature aging,
death). Death comes usually after two to three months.
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Nuclear power plant accidents
1) Three Mile Island, Pennsylvania, 1979: Researchers did not find much adverse effects
after this accident. Because the radiation level was so low that it was not high enough to
cause long term health effects.
2) Chernobyl, former Soviet Union, 1986: Here, the radiation levels were so high that
adverse health effects are even seen today. Many kids born with different abnormalities,
increase in number of cancer cases, changes in vegetation and plants. Most of that
radiation cloud that was produced at Chernobyl went to North Europe, because of
direction of wind. Most of this radiation was settled down at ground level in north
Europe. We still don’t know how much it will affect other countries. Chernobyl accident
had 10-20 times higher dose of exposure than Three Mile Island’s accident.
What parts of our body are most sensitive to radiation? Highly sensitive parts: Lungs,
breast, stomach, colon. Moderate Sensitive parts: brain, lymph tissue, liver, ovaries,
intestines, pancreas, marrow, oesophagus, thyroid. Low sensitive parts: Skin, gall
bladder, kidneys, spleen, bone. These parts are based on acute, whole-body exposure
Is any amount of radiation safe? Some scientists believe yes, and even some lower level
of radiation can be beneficial. How do we know that radiation causes cancer? Before
humans had much information about radiation, or had high technology, they still saw the
problems associated with it. In 1910, it was first observed that radiation causes skin
cancer. Then they found more proof that this is true by studying Japanese atomic bomb
blast survivors, Uranium miners, after medical treatments (if acceptable level of radiation
is exceeded during medical treatments, those cases are used for studying as radiation can
be good or bad if radiation levels exceed normal levels). What we know for sure from
studies is that children are more sensitive because their cells grow faster than adults.
Because of this growth of cells children are more affected.
Chemical properties of radio nuclides: Each radio nuclides have their own chemical
properties. These properties are the same for that form that has a radio nucleic property
and that form that does not have radio nucleic property. For example, iron can be
radioactive or can be regular iron. But they have exactly the same chemical properties.
That element, such as iron, is necessary element (micronutrient) for our bodily functions,
but our body will not know. Our system will not recognize that it is a radioactive iron,
because radioactive iron and regular iron have exactly same properties. Our body will
absorb radioactive as well as non radioactive iron. Chemical properties determine
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