STAT141 Lecture Notes - Lecture 39: Phosphate, Endergonic Reaction, Hydrolysis
14 Oct 2016
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1. All ten steps of glycolysis must have negative change in free energies (deltaG) for glycolysis
to occur
A. true
b. false
2.The phosphorylation of fructose -6-phosphate is an endergonic reaction with a deltaG0 of
16.3kJ/mol. How do cells overcome this thermodynamic barrier for this reaction under standard
conditions?
a. this reaction will proceed to the right because the Keq is small and thus energetically favorable
b. the enzyme that catalyzes this reaction couples it with the condensation of ADP and inorganic
phosphate, resulting in an overall deltaG0 of -46.8kj/mol
c. This reaction will proceed to the right because there is always a large amount of glucose
available to shift the equilibrium towards products.
d. the enzyme that catalyzes this reaction couples it with the hydrolysis of ATP to ADP and
inorganic phosphate, resulting in an overall deltaG0 of -14.2kj/mol
3. Which of the following mechanisms describe how metabolic pathways can be regulated?
select all apply
a. the kinetics of the enzymes are regulated
b. enzymes may be sequestered from substrate in cellular compartments
c. genes that code for enzymes in metabolic pathways may be expressed or repressed
d. the pressure inside cells is changed
4. which of the following processes would most likely occur when cellular energy status is
elevated? select all apply
a. de novo lipid synthesis
b. fructose metabolism
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