Class Notes (811,039)
Canada (494,452)
Statistics (237)
STAT151 (146)


2 Pages
Unlock Document

University of Alberta
Gregory Wagner

BIOL207 B01 Lec07 2014-01-20 CHAPTER 4 A. Definitions 1. Mutation = change i. Change in DNA sequence and/or phenotype … ii. Not all mutations results in mutant phenotypes iii. Not all mutations are deleterious 1. can be neutral 2. can give a selective advantage 3. can be deleterious (can be selective disadvantage) iv. Most mutations that affect a protein coding gene or its expression are loss -of- function mutations 2. All variation in DNA comes from mutation i. Polymorphism (rather than mutation) describes variants that are common in a population (>1%), and for which no obvious “wild -type” allele can be distinguished B. Origins of mutations 1. spontaneous OR induced (purposeful or not) 2. biological, chemical, physical mutagens i. mutations of biological origin 1. DNA strand slippage a. Tandem repeats of simple sequences (di-, tri-, tetra- nucleotides) are prone to mistakes (i.e. slippage) during replication b. This can cause increase or decrease in the number of repeats present at a given locus c. Slippage occurs frequently enough to produce polymorphisms that can distinguish individuals in a population, but is usually heritable between generations d. SSR = simple sequence repeat = microsatellite loci 2. Transposable elements Barbara McClintock a. Two main classes i. Class I : move by copy/paste of an RNA
More Less

Related notes for STAT151

Log In


Don't have an account?

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.