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Lec31_140328.pdf

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Department
Statistics
Course
STAT151
Professor
Gregory Wagner
Semester
Winter

Description
Lec31 BIOL207 2014-03-28 CHAPTER 11 Genomics cont’d video: DNA - Episode 3 of 5 - The Human Race - PBS Documentary https://www.youtube.com/watch?v=MJu9dL7a3ZI A. Genome Assembly a. Need for assembly of genome sequencing projects i. chromosomes are longer than sequencing reads ii. based on overlaps in sequences, individual reads can be assembled into contigs b. initial genome sequencing projects (human, Arabidopsis) assumed it would be too difficult to assemble an entire genome all at once; these broke the genome into large fragments (cloned as BACs), each BAC was put in order relative to each other (i.e. a physical map ), and then each BAC was sequenced and assembled individually (clone -by-clone) c. contemporary genome projects use a whole -genome shotgun sequencing strategy: simply fragment the DNA into many small pieces and assemble them back into the entire genome sequence d. note that repetitive sequences complicate genome assembly B. Functional Genomics a. Study gene expression on a large scale i. Gene expression is regulated by: 1. Transcription: how much transcript is present for each gene a. Affected by both initiation of transcription and RNA turnover 2. Translation: how much protein is made from each transcript 3.
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