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Lec24_140310-2.pdf

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Department
Statistics
Course
STAT151
Professor
Gregory Wagner
Semester
Winter

Description
Lec 24 BIOL207 2014-03-10 CHAPTER 9 A. Changes in chromosome number Nondisjunction http://www.youtube.com/watch?v=7Y-pCgdfLeA a. Failure of sister chromatids or pairs of homologs to divide during meiosis I or meiosis II or mitosis b. Can lead to a trisomy (2n+1 = extra copy of one chromosome) or to monosomy (2n-1); both are examples of aneuploidy B. Changes in chromosome structure caused by incorrect repair of double-strand DNA breaks a. NHEJ (non-homologous end joining) proteins recognize ds (double stranded) breaks in DNA and repair them by rejoining two free ends of non telomeric dsDNA together b. NHEJ does not look for sequences that belong together before rejoining them c. NHEJ of “wrong” ends can lead to deletion, inversion, duplication, or translocation d. note that single strand breaks (nicks) are repaired by ligase C. Changes in chromosome structure caused by incorrect c
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