ZOOL342 Lecture Notes - Lecture 6: Voltage Clamp, Electrophysiology
21 Jan 2019
School
Department
Course
Professor
Document Summary
Blocking the na channel, will only see the outward current due to k+. Blocking the pore, not the gate in the channel. At -50mv, there is some inward na and outward k current. 30, -20mv we see larger na and k currents. The amplitude of the na, does not change anymore; not bigger but still inward current. K is still getting bigger while na is levelling off. Na after 0mv, starts getting smaller while the. K gets larger from 0mv. (b) late current, k and early, na. At some point, na becomes outward as it gets smaller. When na becomes outward, the equilibrium potential of na, the amount of the current is zero. I=g(vm-ena) we get 0 current, then conductance or the vm=em becomes 0. There is no more driving force for the ion to ow, because the ion wants to be at its equilibrium potential. -40-50= -90 if vm goes to 0-50= -50.
