BIOL 435 Lecture 19: 2012 Lecture 19 Neurulation - revised

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Speci cation of neural fates occurs prior to any morphological changes. Signals emanating from the adjacent tissues pattern the nervous system. Regional speci c transcription factors are activated in response to morphogen gradients. Expression of these transcription factors speci es cell position along the anterior/posterior axis. Interactions between the ectoderm and neighboring tissues specify the neural precursor cells (neuroblasts)! Competence: if exposed to appropriate signals, multipotent cells are capable of forming neuroblasts. Speci cation: cells have received signals needed for neural differentiation, but progression can be blocked by other signals. Commitment (determination): cells begin the neural differentiation pathway and will become neurons even in the presence of inhibitory signals. Differentiation: neuroblasts leave the mitotic cycle and express genes characteristic of neurons. Primary neurulation: cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow tube. !

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