CMMB 403 Lecture Notes - Lecture 9: Inner Cell Mass, Embryonic Stem Cell, Yolk Sac

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Concept of the day: the potency of stem cells. Stem cells are those cells that can divide to replicate themselves and they can produce daughter cells that can differentiate into other cell types. The specific diversity of cell types that a stem cell can generate defines its potency. Totipotent stem cells (eg. zygote, the origin of all development) can generate all the cell types of the embryo and extra-embryonic tissues (eg. the embryonic portion of the placenta, or chorion, the amnion and the yolk sac) All development is dependent on stem cells, starting with the single totipotent stem cell that is the zygote. Even after division, blastomeres may remain totipotent (can form 2 embryos monozygotic twins, identical) Up to the 8 cell stage, blastomeres remain totipotent. Only for mammals (eg. mice and humans) Called so because it forms a fluid filled cavity known as blastocoel.

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