CMMB 403 Lecture Notes - Lecture 6: Dorsal Root Ganglion, Hoxa11, Limb Development

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When and where an enhancer is active. When and where a reporter gene is expressed. When an where mrna is expressed of a specific gene. Limiting cre expression to a particular tissue/cell type. Every cell would remove the gene that is expressing cre. All cells will have the lox gene. In the heart, dorsal root ganglia, and palate it is expressed. It is not expressed in the distal limb, but it is in the proximal limb (closer to heart) Disprosopous (having 2 heads, or half a head duplicated) Find where the expression of the cre and that gene overlap. Locate abnormal structures in an embryo expressing the cre, but, in this embryo it is not going to have anything deleted yet so it will be hard to determine. Hoxa11 in middle (aka zeugopod), hoxd13 in distal segment (autopod) Autopod is in distal (because higher number) Same number of segments, posterior deleted/anterior mirror imaged.

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