CMMB 413 Lecture Notes - Lecture 16: Henrietta Lacks, Metastasis, Hela
30 Apr 2019
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Cancer is a disease of a genome. Normal field mouse has only 1/3 of the number of cells that make humans, live less than us but have about the same cancer risk. Not related to number of cells and lifespan. Normal cells will experience low grade cell division, little too much growth (hyperplasia) Displasia: growth of cells that is out of control and not orderly, incorrect growth, if not checked, leads to large mass of incorrectly growing cells (benign growth, lump in skin), eventually becoming malignant. Malignant: uncontrolled, these migrate away from site of mass, and enter blood stream or lymphnodes to create secondary cancer (metastasis) in other sites. Liver and lung cancer is the most common site of metastatic growth because they are nice capillary beds. Most cells in the body won"t start dividing unless something tells them to.
