KNES 323 Lecture Notes - Lecture 10: Contracture, Golgi Tendon Organ, Phosphocreatine
26 Feb 2016
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Levels of organization: (slides 6-8 for detailed diagrams on internal muscle contraction. Use to draw out its layout and note important parts)!!!!!!!!!!!!! Muscle group muscle fascicles (bundles) muscle fibres (cells) myofibrils . Actin: double helix, binding sites for myosin, which are covered my tropomyosin. Only activated when ca binds to troponin, giving myosin something to grab onto. Located at center of string, provides elasticity and structure. Nebulin aligns actin, keeps it in a straight line, located in center of double helix. Creates end plate potentials (epp) travels down t-tubules to the sr. This opens ca gates, which causes an influx of ca. Ca binds troponin, shifts tropomyosin out of the way, and causes crossbridges contraction! Contraction: (know these changes during contraction for the final!!!!!!!!!) Ca and atpase pumps on sr decrease in ca pulls off troponin tropomyosin shifts back actin and myosin slide back. Latent period = time between ap and contraction (gets longer with increased load for lab!!)
