KNES 433 Lecture Notes - Lecture 14: Vascular Smooth Muscle, Low-Density Lipoprotein, Atheroma
11 Apr 2018
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Lecture 14 atheroma: atherosclerosis as the main contributor to cad causes fatty cholesterol-filled plaque build ups that obstruct blood flow. Irritants include lipids like ldl cholesterol, toxins like cigarette smoke, and high blood pressure. Atherosclerosis = thickening and hardening of arterial walls as a consequence of atheroma. Ester/free cholesterol: 4 factors weakening the cap: collagen synthesis, collagen degradation, Macrophages/t-cells, # of smc: 4 clinical effects of atheroma: + ldl most significant (taken up by ecs) + hdl are protective: cigarette smoking major rf for ihd but risk can and lungs can recover after giving up. May cause increased platelet aggregation or trigger coagulation system or reduce prostaglandin 12 (which vasodilates and reduces platelet aggregation: hypertension strong link b/w ihd and high sp/dp but (cid:374)ot (cid:396)eally su(cid:396)e (cid:449)hy may cause endothelial damage w/ pressures. Forces can induce gene expression in ec that cause them to be more atherogenic: diabetes mellitus doubles ihd risk, can increase risk of cerebrovascular and.
