KNES 437 Lecture Notes - Lecture 4: Twin, Leptin, Twin Study

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Genetic mutations are powerful in severe, early onset obesity: once babies are born, if theres a genetic issue, they put on a lot of weight fast, 2. Study of genetics may lead to safe & specific drugs: 3. Heritability: heritability = the proportion of the total variation in a gene trait due to genetic factors, passed from one generation to the next. In other words, individual"s chance of being obese increases when they have obese parents or relatives. If both parents are overweight, theres a significant increase in the risk for the child to be overweight. Heritability of fat mass: population measure of variation, 40 to 70% heritability. Obesity gene causing leptin deficiency: the first identified genetic mutation leading to obesity is the gene mutation for leptin deficiency. Leptin is produced from fat cells and registered by the brain. Leptin is released as we are satiated (when we"re full).

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