Acromegaly results from excess secretion of growth hormone (GH).
It is a rare condition of bone and soft tissue overgrowth.
Bones increase in thickness and width but not length.
Manifestations include enlargement of hands and feet, thickening and enlargement of
face and head bony and soft tissue, sleep apnea, signs of diabetes mellitus, cardiomegaly,
Treatment focuses on returning GH levels to normal through surgery, radiation, and drug
therapy. The prognosis depends on age at onset, age when treatment is initiated, and
Nursing care for surgical patients postoperatively includes avoidance of vigorous
coughing, sneezing, and straining at stool to prevent cerebrospinal fluid leakage from
where the sella turcica was entered.
After surgery with a transsphenoidal approach, the head of the bed is elevated to a 30-
degree angle at all times, and neurologic status is monitored. Mild analgesia is used for
headaches, and toothbrushing is avoided for at least 10 days.
If hypophysectomy is done or the pituitary is damaged, antidiuretic hormone (ADH),
cortisol, and thyroid hormone replacement must be taken for life. Patient teaching is
essential with hormone replacement therapy.
Hypopituitarism is rare, and involves a decrease in one or more of the pituitary
o The anterior pituitary gland secretes adrenocorticotrophic hormone (ACTH),
thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH),
luteinizing hormone (LH), GH, and prolactin.
o The posterior pituitary gland secretes ADH and oxytocin.
Most deficiencies associated with hypopituitarism involve GH and gonadotropins (e.g.,
LH, FSH) due to a pituitary tumor.
SYNDROME OF INAPPROPRIATE ANTIDIURETIC HORMONE
Syndrome of inappropriate antidiuretic hormone (SIADH) results from an
overproduction or oversecretion of ADH.
SIADH results from abnormal production or sustained secretion of ADH and is
characterized by fluid retention, serum hypoosmolality, dilutional hyponatremia, hypochloremia, concentrated urine in presence of normal or increased intravascular
volume, and normal renal function.
The most common cause is lung cancer.
Treatment is directed at underlying cause, with a goal to restore normal fluid volume and
osmolality. Fluid restriction results in gradual, daily weight reductions, progressive rise in
serum sodium concentration and osmolality, and symptomatic improvement. With
chronic SIADH, the patient must learn self-management.
Diabetes insipidus (DI) is associated with deficiency of production or secretion of ADH
or decreased renal response to ADH.
Decreases in ADH cause fluid and electrolyte imbalances due to increased urinary output
and increased plasma osmolality.
Depending on the cause, DI may be transient or chronic lifelong condition.
Types of DI include:
o Central DI (or neurogenic DI) occurs when an organic lesion of the
hypothalamus, infundibular stem, or posterior pituitary interferes with ADH
synthesis, transport, or release.
o Nephrogenic DI occurs when there is adequate ADH, but a decreased kidney
response to ADH. Lithium is a common cause of drug-induced nephrogenic DI.
Hypokalemia and hypercalcemia may also lead to nephrogenic DI.
o Psychogenic DI is associated with excessive water intake, caused by lesion in
thirst center or by psychosis.
DI is characterized by polydipsia and polyuria.
If oral fluid intake cannot keep up with urinary losses, severe fluid volume deficit results
as manifested by weight loss, constipation, poor tissue turgor, hypotension, and shock.
Severe dehydration and hypovolemic shock may occur.
Treating the primary cause is central to management. Therapeutic goal is maintenance of
fluid and electrolyte balance.
Nursing care includes early detection, maintenance of adequate hydration, and patient
teaching for long-term management.
Goiter is thyroid gland hypertrophy and enlargement caused by excess TSH stimulation,
which can be caused by inadequate circulating thyroid hormones. Goiter is also found in Graves’ disease.
TSH and T4 levels are measured to determine if goiter is associated with
hyperthyroidism, hypothyroidism, or normal thyroid function.
Thyroid antibodies are measured to assess for thyroiditis.
Treatment with thyroid hormone may prevent further thyroid enlargement.
Surgery to remove large goiters may be done.
A thyroid nodule, a palpable deformity of the thyroid gland, may be benign or
Benign nodules are usually not dangerous, but can cause tracheal compression if they
become too large.
Malignant tumors of thyroid gland are rare.
A major sign of thyroid cancer is presence of hard, painless nodule or nodules on
enlarged thyroid gland.
Surgical tumor removal is usually indicated with cancer.