NURS 203 Lecture Notes - Arteriolosclerosis, Aldose Reductase, Chlamydophila Pneumoniae
Document Summary
Cells involved- platelets, monocytes, macrophages, cytotoxic t cells with cytokines (neutrophils not involved) Ammonia in cig smoke, co in cig smoke; so, poisons damage the endothelial cells; ldl damages it, and if its oxidized, it damages it worse; viral infections damage it, too. Chlamydia pneumoniae (2nd mcc atypical pneumoniae); pts with mi most had ab"s against chlamydia pneumonia, homocysteine all these things damage endothelial cells. Platelets stick to it and pdgf is released into the artery and pdgf causes smooth muscle cells within the media to proliferate and they undergo hyperplasia and then, they chemotactically migrate to the subintimal level. They have all these smooth muscle cells migrating to the intima of the vessel. Monocytes have access into the vessel b/c it has been injured and monocytes also have gfs. As the ldl increases, the macrophages phagocytose them. Macrophages and smooth cells have ldl w/in them; the ldl becomes oxidized and a fatty streak is produced.
