NURS 203 Lecture Notes - Systemic Scleroderma, Dystrophic Calcification, Cold Agglutinin Disease
Document Summary
There are many causes this; some involve cold reacting ab"s and cold reacting globulins. People who go outside in the cold weather will get raynaud"s and cyanosis in the nose and ears (that comes and goes away); so, it is due to igm cold agglutinin dz or cryoglobinemia in old man with. However, we have other dz"s that are collagen vascular dz and first manifestation is raynaud"s; this involves a digital vasculitis and eventually a fibrosis progressive systemic sclerosis (aka scleroderma), and its counterpart crest syndrome. Vasculitis of fingers and leads to fibrosis will eventually auto-amputate finger (like berger"s). Crest syndrome calcinosis (dystrophic calcification) and centromere ab (specific for crest syndrome), raynaud"s, esophageal dysmotility, sclerodactyly (finger that is very narrow), Telangiectasia (very similar to the pin point hemorrhages also seen in osler weber. Other causes due to vasoconstriction common in pts that take drugs for migraine drugs for migraines cause vasoconstriction of vessels.
