ANSC 4650 Lecture Notes - Lecture 7: Neutrophil Extracellular Traps, Granulopoiesis, Granulocyte

• School: University of Guelph
• Department: Animal Science
• Course: ANSC 4650
• Professor: Niel Karrow

Document Summary

Specific granules: packaged later in development and contain, adhesion molecules, tnf receptors, collagenase, iron binding proteins (lactoferrin and haptoglobin) Gelatinase granules: packaged even later and have, adhesion molecules, matrix metalloproteinases (mmps, remodel extracellular matrix to increase ease of cell migration through tissues, cleaves chemokines to increase or decrease bioactivity, tnf receptors, lysozyme, arginase. Il-1: tnd-a, cxcl8, c5a, ltb4, paf, neutrophil activation requires 2 signals. Paf, pamps and host alarmins: chemotactic agents detected by receptors on the neutrophil. Oxygen independent killing via rlease of lytic enzymes and cationic peptides which bind to bacterial/fungal surfaces and disrupts the cell membrane. Mpo (myeloperoxidase) is present: mpo can also make hypochlorite (kills by oxidizing membrane proteins and lipids and enhances lysosomal enzyme activity, h202 can also react with iron to make highly reactive hydroxyl radicals via. Diverse functions of defensins: disruption of microbial surfaces, chemoattractants for neutrophils, macrophages, dendritic cells, monocytes and fibroblast cells.