ANSC 4650 Lecture Notes - Lecture 12: Bone Marrow, Pronephros, Antigen Presentation

• School: University of Guelph
• Department: Animal Science
• Course: ANSC 4650
• Professor: Niel Karrow

Document Summary

Development of b-cells: similar to t-cells and nk-cells, come from lymphoid stem cells from bone marrow equilvalent tissues, pre-b cells colonize bone marrow equivalent tissue where they mature into. B-cells: bone marrow equilvalent tissue, pronephros fish, bursa of fabricius birds, bone marrow/peyer"s patches. Centeres, they expand or multiply and undergo class switching from igm to. Igg, iga or ige: class switching heavy chain gene rearrangement so the plasma cells can make different immunoglobulins, directed by b cells cd40-th-cell cd154 ligation with the help of cytokines. In mice il-4 needed for igg1 and ige production. Ifn-y is needed for igg2a and igg3 production: tgf-b is needed for iga production. Immunoglobilin class ch domains: depending on the immunoglobiin isotype and species, the c-region of the h chain is made of differently number of domains and sometimes a hinge region, gives flexibility (specificity) Apcs than macrophages as they are antigen specific and can recognize native antigens.