BIOC 2580 Lecture Notes - Lecture 20: Gerty Cori, Pyruvate Decarboxylase, Lactate Dehydrogenase

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Acetyl coa - with oxygen and enters citric acid cycle. Under anaerobic conditions, animals reduce pyruvate to lactate regenerating the nad+ used by g3p. Dehydrogenase (middle with lactate: under aerobic conditions, nadh generated in glycolysis cannot be oxidized through the etc. Have glucose to form 2 pyruvate, which will form. Nadh which have to convert back to nadh+ Carl and gerti cori: glycogen breaks off glucose subunits which enter glycolysis and generate. Yeast and other microorganisms convert pyruvate to ethanol and co2 under anaerobic conditions: Under aerobic conditions nadh is oxidized by the electron transport chain with o2 as the ultimate. Special shuttle systems are required to carry reducing equivalents from cytosolic nadh to. Mitochondria as the imm is impermeable to nadh: 1. + nad+ which goes to the etc: malate needs to get out of matrix so once converted to oxlaoactete turns to aspartate which uses transporter to het out then is converted back to oxaloacetate, 2.

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