BIOC 2580 Lecture Notes - Lecture 21: Oxidative Phosphorylation, Acetyl-Coa, Malate Dehydrogenase

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Glycolysis is the central pathway in carbohydrate metabolism and, therefore, in metabolism overall. It occurs as the monosaccharide (simple sugar), combined with fructose in the disaccharide sucrose (table sugar), and in polymeric forms such as glycogen, cellulose, and starch. We will use the term glycolysis (from the greek words for sugar + breakdown) for the sequence of reactions leading from glucose to the three-carbon compound pyruvic acid. Many additional pathways lead from other sugars to glucose (convergent catabolism), but we will not discuss them here. Glucose is a critical source of metabolic energy for many organs - notably the brain. The brain consumes about100 grams of glucose daily. Therefore, it is not surprising that multiple mechanisms exist that act to maintain blood glucose levels. The usual concentration of blood glucose in a fasting human is about 5 mm, making it one of the most abundant small molecules in the body.

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