BIOC 2580 Lecture Notes - Lecture 15: Triosephosphate Isomerase, Malate Dehydrogenase, Succinyl-Coa

37 views7 pages

Document Summary

Fatty acids are prepared for catabolism by activating them to fatty acyl coa and occurs before beta oxidation can proceed. Process: the nucleophilic oxygen atom of the fatty acid (nucleophile) attacks the alpha phosphate of the atp (the electrophile) forming ppi and acyl adenylate by the enzyme: acyl-coa synthetase. The ppi is immediately hydrolyzed to 2pi by the enzyme: inorganic pyrohosphatase: the thiolate anion forms of coenzyme a, as the nucleophile reacts with the acyl adenylate by the enzyme: acyl coa synthetase. Amp is the leaving group and fatty acyl co-a thioester is formed. Fatty acids are transported into the mitochondrial matrix via acyl-carnitine in the form of fatty acyl-carnitine. Each round of beta-oxidation produces 1 fadh2 per turn, 1. Nadh per turn and 1 acetyl coa per 2 carbons. Fadh2 by the enzyme: acyl-coa dehydrogenase converts. Palmitoyl-coa into trans-delta2-enoyl-coa: oxidation of l-beta-hydroxy-acyl-coa by nad, water is added across the double bond and trans-delta2-enoyl-coa is converted.

Get access

Grade+20% off
$8 USD/m$10 USD/m
Billed $96 USD annually
Grade+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
40 Verified Answers
Class+
$8 USD/m
Billed $96 USD annually
Class+
Homework Help
Study Guides
Textbook Solutions
Class Notes
Textbook Notes
Booster Class
30 Verified Answers

Related Documents

Related Questions