BIOC 3560 Lecture Notes - Lecture 1: Dissociation Constant, Histidine, Coordinate Covalent Bond

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chocolatelion965

16 Sep 2017

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Properties of interest: size, molecular weight, hydrophobicity/ hydrophilicity, there is strong relation between a proteins structure and its function, protei(cid:374) stru(cid:272)tures are(cid:374)(cid:859)t flat charge. Reversible modification of protein function: proteins are dynamic molecules, function is influenced by interactions w other molecules. Interactions can be stable (on all the time and req. for protein to function) or transient (reversible, not on all the time) Prosthetic groups vs ligands: stable interactions: prosthetic groups are molecules that are permanently associated w a protein and is req. for its function, transient interactions: a ligand is a molecule that is bound reversibly by a protein. Binding sites and ligands: binding site: region of a protein surface that interacts with a ligand, complementary to ligand in, size, shape, charge, hydrophobicity/hydrophilicity. Interactions are highly specific: proteins can have 1 binding site. Induced fit: structural adaptation between protein and ligand. Conformation change can make binding site more complementary for optimal fit.

Related Questions

33 Different glycoproteins can have a diverse array of oligosaccharides. Which of the statements below for making glycoproteins on plasma membrane is true?

(a) Extensive modification of oligosaccharides occurs in the extracellular space.

(b) Initial oligosaccharide chains are made by addition of one sugar at a time onto the protein in the ER lumen.

(c) Each layer of Golgi membrane structures contains identical modification enzymes for modifying sugar chain on proteins.

(d) ER lipids can be modified by sugar chain, which can be used for sugar chain modification of the proteins.

34 In a multicellular organism, when a signal needs to be sent to most cells the signal most suited for this is a ___________.

(a) neurotransmitter.

(b) hormone.

(d) plasma membrane anchored ligands.

35 Typically, members of the steroid hormone receptor family __________________.

(a) are cell-surface receptors.

(b) do not undergo conformational changes by binding to their ligands.

(d) interact with signal molecules that diffuse through the plasma membrane

36 Which of the following statements about what happens when a G-protein-coupled receptor activates a hetero trimeric G protein is true?

(a) The Î² subunit exchanges its bound GDP for GTP.

(b) The GDP bound to the Î± subunit is phosphorylated to form bound GTP.

(d) It activates the Î± subunit and inactivates the Î²Î³ complex

37 Which of the following statements about signal transduction is false

(a) Ca2+ concentration in cytosol will increase when PLC (Phospholipase C) is activated by signal.

(b) Cyclic GMP is made in smooth muscle cells when they received NO signal.

(d) Ligand binding to RTK activates its enzyme activity then the activated RTK phosphorylates tyrosine residues on itself.

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BIOC 3560 Lecture Notes - Lecture 1: Dissociation Constant, Histidine, Coordinate Covalent Bond

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