BIOC 4580 Lecture Notes - Lecture 12: Thiol, Glut1, Lipid Bilayer
22 Mar 2018
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Document Summary
Size, polarity, charge govern rates of diffusion across lipid bilayers. Charged and polasr molecules must shed their hydration sphere before passing through gaps. Erythrocyte glucose transporter (glut1) and the glut family. Glut1 is a member of a large family of proteins with 12tm segments. Major facilitator (mf) superfamily of sugar transporters found in all organisms from bacteria to humans. 12 glut family members exist in the human genome (glut1-glut12), with different tissue distribution, kinetic properties and regulation. All move glucose down its concentration gradient in a manner that is fast, specific, saturable and susceptible to competitive and chemical inhibition. Exhibits characteristics that differentiate mediated from non-mediated transport. Speed and specificity: distinguishes d-glucose from d-mannitol, which would diffuse through the lipid bilayer at similar rates. There are a number of specific, saturable sites on the membrane that are involved in glucose transport.
