BIOL 1070 Lecture Notes - Lecture 5: Endoplasmic Reticulum, Lipid Bilayer, Membrane Transport Protein
15 May 2018
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Biol 130 Worksheet Unit 6
Membranes
Terms:
active transport
amphipathic
antiport, symport, uniport
apical versus basolateral
Ca-pump (Ca-ATPase)
channel
cholesterol
cotransport
diffusion
dynamic equilibrium
electrochemical gradient
epithelium, epithelial cell
facilitated diffusion
flippase
fluidity
flux, influx, efflux, net flux
hydrophilic / hydrophobic
integral / peripheral membrane proteins
leaflet
lysis
membrane domains
membrane transporter
multipass membrane protein
Na-K pump (Na-K ATPase)
osmosis, osmolarity
passive transport
permeability
scramblase
tonicity, hyper/hypo/isotonic
transition temperature
Match the definition below with its term from the list above:
1. the temperature at which a membrane changes from a liquid to a gel (or vice versa)
2. an enzyme expressed on the cytosolic leaflet of the ER membrane that moves phospholipids to the
non-cytosolic layer
3. an enzyme that plays a major role in generation of membrane asymmetry in the Golgi
4. proteins attached to one face of a membrane by non-covalent interactions with other membrane
proteins
5. protein whose polypeptide chain crosses the lipid bilayer more than once
6. an aqueous pore in a membrane, with walls made of proteins
7. movement of a small molecule or ion across a membrane due to a difference in concentration or
electrical charge
8. a situation in which molecules are moving back and forth across a membrane but their concentrations
are the same on both sides of the membrane
9. a solution that contains less solute than what it is being compared to (often compared to a cell)
10. general term for a membrane-embedded protein that serves as a carrier of ions or small molecules
from one side of the membrane to the other
11. movement of a molecule or ion across a membrane that is driven by ATP hydrolysis or some other
form of metabolic energy
12. driving force for ion movement
13. membrane carrier protein that transports two different ions or small molecules across a membrane in
opposite directions
14. carrier proteins that transport two types of solute across the membrane in the same direction
15. regions of a plasma membrane that are composed of different lipid or protein components compared
to the rest of the cell
16. the region of an epithelial cell most likely to express carriers mediating Na+/glucose coupled transport.
TRUE / FALSE, explain:
1. Membrane phospholipids spin in place and travel through the leaflet but ‘flip-flop’ from one leaflet to
the other only rarely, with the help of enzyme catalysts.
2. Once membrane asymmetry is established in the endoplasmic reticulum is maintained in all other
membranes of a eukaryotic cell.
3. All the carbohydrate in the plasma membrane faces outward on the external surface, whereas all the
carbohydrate on internal membranes faces toward the cytosol.
4. Mammalian red blood cells contain no internal membranes other than the nuclear membrane.
5. The plasma membrane is permeable to all charged molecules.
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