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University of Guelph
BIOL 1080
Jim Kirkland

1/5/2013 BIOL 1080 - Biological Concepts of Health Winter 2012 Instructor: Dr. Jim Kirkland [email protected] Course Coordinator: Dr. Justine Tishinsky [email protected] Office Hours: Dr. Kirkland - (Rm. 335, ANNU) for individual or group discussion of class or related health topics; Monday and Wednesday: 1:30 - 2:30 pm. Dr. Tishinsky - (Rm. 340, ANNU) for individual appointments concerning disease seminar, independent learning lab and IDP material and course activities; Tues/Thurs 9:30-10:30 am. Textbook:Biological Concepts of Health Custom Edition for the University of Guelph (required - some exam material will come from the assigned textbook readings) NOTE*** This BIOL 1080 class section, scheduled from 4:30 - 5:20 pm on Mon/Wed in ROZ 104, is meant to be considered a separate class from the other sectional offering of BIOL 1080. The questions on the mid-term and final examinations may not be identical in the two sections of the course. More▯Class▯Info ▯Questions/ideas are encouraged during class! ▯The course website has a daily update of the CBC Health News wireservice. Students interesetd in health are encouraged to keep track of current health issues in society. This is a ‘real world’-oriented course – and not jusitn the final problem solving i lil bexertcielohn human health and a global environmental issue. ▯Dr Kirkland will have a ‘Lecture Afterthoughts’ section on the course website which, hopefully, will help to encourage further consideration and application of the topics that come up in class discussions and in the Health News wireservice. ▯Finally, please beware that it is VERY DIFFICULT to speak aboouttssuessoffhumaan heealh andddiseaase wihooutsttuggllng oto find words that do not distress, confuse or offend a listener ( in class/labs/seminars/discussion board). Health is a very PERSONAL topic. At the very least, start with the assumption that the person sitting next to you, or someone within hearing distance, suffers from the disease or disorder you are speaking about! Collectively, we will all do our best to show maturity and sensitivity – both as speakers and listeners… 1 1/5/2013 An▯inuksuk▯(▯▯▯▯▯)▯is▯a▯stone▯landmark▯▯ built▯by▯humans,▯used▯by▯the▯Inuit,▯Inupiat,▯ Kalaallit,▯Yupik,▯and▯other▯peoples▯of▯the▯ Arctic▯region▯of▯North▯America. The▯inuksuk▯may▯have▯been▯used▯for▯ navigation,▯as▯a▯point▯of▯reference,▯a▯marker▯ orrhunttng▯grounnds,orras▯a▯ooddcacche. The▯word▯inuksuk▯means▯"something▯which▯ acts▯for▯or▯performs▯the▯function▯of▯a▯ person."▯The▯word▯comes▯from▯the▯ morphemes▯inuk ("person")▯and▯▯suk ("ersatz"▯or▯"substitute") Wiikipedia)) In▯the▯BIOL▯1080▯class,▯we▯▯use▯the▯inuksuk▯to▯ represent▯the‘hidden▯complexity▯of▯ living▯organisms’▯ . Photo:▯Andre▯Nantel (systems▯biologist!) *** This▯class▯▯will▯frequently▯▯address▯newly▯appreciated▯▯levels▯of▯complexity▯ of▯life▯and▯ouncertainty in▯the▯study▯of▯biological▯science.▯▯Sometimes▯these▯topics▯go▯ beyond▯the▯material▯covered▯in▯the▯course▯▯textbook.▯In▯such▯cases▯the▯faculty▯▯have▯ written▯essays▯or▯chapters▯to▯augment▯the▯textbook▯material;▯ Example▯▯ the▯textbook▯says…▯there▯are▯11▯major▯organ▯systems▯which▯make▯up▯the▯adult▯ human▯(textbook,▯p.▯63).▯▯In▯a▯later▯class,▯▯we▯will▯be▯studying▯a▯major▯organ▯system▯ called▯the▯▯“Energy▯Distribution▯System”▯–which ▯is▯a▯system▯▯critical▯to▯understanding▯ health.▯▯There▯is▯a▯chapter▯about▯this▯system▯on▯our▯the▯course▯website. Part▯of▯the▯value▯in▯teaching▯about▯the▯Energy▯Distribution▯System▯is▯that▯the▯system▯ emphasizes▯that▯‘adipose▯tissue’▯▯does▯much▯more▯than▯ ‘store▯energy,▯provide▯ i tlsulation▯and▯cushiion▯organs’’textbook,▯pp.588,59)) 2 1/5/2013 Biological Concepts of Health A New Era in Biology The overall objective of BIOL 1080 course is to consider the concepts of Health, Disease and Aging from a “Systems Biology’ perspeectve. The term ‘Systemss Biology’wiilserve, n ths couurse,as a shorthand version of the 5 core concept of Biology, namely, ‘Logic Units and Information Flow in Biological Systems’. While manyy pf ye yrinciples,f Systems Biology can be scaled, in terms of level of organization, from the molecular to the ecosystem levels, this course will focus on the individual, adult human biological system for an examination of the topics of health, disease and aging. BIOL*1090 BIOL*1080 BIOL*1070 3 1/5/2013 What are the Biological Concepts of Health from the systems biology perspective of the adult human? 1. Each adult human can be considered as a unique biological system. 2. The adult human biological system has a Control and Commmmuunicatonn Netwoork thattcoordinaates hee unnctonns offhee personn. 3. The Control and Communication Network is the logic unit of the human adult; the role of the Network is to direct information flow in the system. 4. The Control and Communication Network is the locus of health in the adult human. 5. Both aging and disease are concepts and processes which represent compromised structure/function of the Control and Communication Network. 6. A Systems Biology/Control and Communication Network-based approach to health, disease and aging is anticipated to facilitate enhanced Medical and Healthcare Practice. What are the Biological Concepts of Health from the systems biology perspective of the adult human? 1. Each adult human can be considered as a unique biological system. In▯spite▯of▯our▯remarkable▯genetic▯similarity▯to▯primates▯like▯chimpanzees▯ (98%+++genetichomoology)and▯evento▯nsects▯ke▯ruit▯ess▯65%▯genetc▯c homology),▯it▯is▯the▯emergent▯properties▯of▯the▯adult▯human▯biological▯ system▯that▯makes▯humans▯unique▯animals▯in▯the▯biosphere.▯ In▯spite▯of▯the▯genetic▯similarity▯among▯humans▯(99.9%▯genetic▯homology),▯ emergent▯properties▯produce▯incredible▯variation▯among▯individuals▯within▯ the▯human▯species.▯▯This▯is▯occurs▯to▯such▯an▯extent▯that▯the▯concept▯of▯ human▯races,▯and▯ethnic▯geographic▯identities,▯is▯disputed▯because▯the▯ difference▯between▯individuals▯‘within▯a▯‘race’▯exceeds▯any▯difference▯we▯can▯ find▯‘between▯races’.▯ .▯ 4 1/5/2013 What makes humans the ‘unique-ier-est’ of all animal species? What is health in a species with this astonishing level of complexity? This▯is▯a▯TED▯Talk▯by▯Dr.▯Robert▯Sapolsky,▯professor▯of▯Biology▯and▯ Neuroscience▯at▯Stanford▯University.▯He▯is▯world▯renowned▯as▯primatologist▯ (studies▯baboons)▯who▯studies▯the▯
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