BIOL 1080 Lecture Notes - Lecture 6: Cyclic Adenosine Monophosphate, Autocrine Signalling, Glycogenolysis
Document Summary
Goal : trying to change the metabolic activity of the cell. Lipid : turn on your genes, by changing the protein shape can also turn off the genes that make new proteins. Regardless of how the messenger enters the cell, it ends up in a hormone-receptor complex in the nucleus. Amplification : although there is only one hormone receptor, multiple mrna can be formed and thus many proteins can be formed camp = 2nd msnger. Slide 5 -7 : signal transduction hydrophilic. Activates hormone sensitive lipase ( targets trigylcerides) Activate lipolysis and release of fatty acids. Consequence of camp activation in various target tissues: muscle: facilitate glycogenolysis (glycogen phosphorylase) and lipolysis (hormone sensitive lipase). Relatively minor role, because in muscles, when epinephrine is released, camp is activated, thus activating, glycogenolysis and lipolysis. The effects are less pronounced in muscles because skeletal muscle is unlike any other tissue, it"s energy consumption increases many more signals.