BIOL 1090 Lecture Notes - Lecture 11: Cytosol, Cytoskeleton, Motor Protein

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The cytoskeleton: chapter 9: a dynamic network of protein filaments that forms the cellular scaffolding as well as transport system for organelles and vesicles. Three major elements: microtubules hollow, unbranched tubules of tublin outer diameter 25nm. Intermediate filaments fibrous, various proteins diameter 10-12 nm: microfilaments solid, thin, branched, actin polymers diameter 8 nm. In vivo, this leads to rapid turnover of most mts within cell (half-life is minutes) (cid:858)dy(cid:374)a(cid:373)i(cid:272) i(cid:374)sta(cid:271)ility(cid:859) shri(cid:374)kage (cid:272)a(cid:374) o(cid:272)(cid:272)ur very rapidly at the (cid:858)plus(cid:859) e(cid:374)d (cid:894)ter(cid:373)ed (cid:858)catastrophe(cid:859)(cid:895) Microtubule-organizing centre (mtoc) = central site of mt assembly. ***** the centrosome is a major mtoc in animal cells ***** formation of mts is regulated/controlled by microtubule- Mediate interactions with other cellular structures (e. g vesicles/organelles) Use atp to generate force: non-motor maps: Control mt organization in cytosol (cid:272)a(cid:374) (cid:373)ove (cid:373)aterial alo(cid:374)g mt (cid:858)tra(cid:272)k(cid:859) can generate sliding force between mts (e. g tau protein in neurons)

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