BIOL 1090 Lecture Notes - Lecture 19: Lipofuscin, Invagination, Solution
16 Dec 2017
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March 20, 2017 l19: vesicles, lysosomes, vacuoles, and peroxisomes. Retrieval of resident er proteins: amino acid sequence that directs protein back to er = er retrieval signal. Kdel receptors in membranes of cgn and cis golgi bind to retrieval signal of escaped proteins. Kdel receptors bind to copi complex proteins and are incorporated into copi vesicles. Escaped proteins reach the er in (copi-coated) retrograde transport vesicles: clathrin-coated vesicles (ccvs) move from tgn to other vesicles ex. Lysosomes, endosomes, plant vacuoles: clathrin forms a triskelion", composed of 3 heavy and 3 light chains. Triskelions interact create a polyhedral lattice, a basket like structure that surrounds a vesicle: ccv-adaptor proteisn b/w clathrin lattice ad the cytosolic face of the vesicle. Selectively sort cargo at tgn, cell membrane and endosomal compartments: orientation of a protein w/respect to the cytoplasm and the interior of membrane- bound compartments is maintained during its travel through the endomembrane system.
