BIOL 1090 Lecture Notes - Lysosome, Golgi Apparatus, Mitochondrion

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Lysosomes the organelles within the cell do not arise from an assembly of parts from the cytoplasm; they are generated from within the cell the cell can regenerate itself. Variable size (<1 m: small compared to the golgi, similar size of vesicles internal ph of 4. 6 (acidic) Need to be contained; dangerous to any other part of the cell lysosomal membrane: protective lining next to lumen inner leaflet has many glycosylated proteins to contain the hydrolytic enzymes. Another example of the purpose and importance of glycosylation of electron micrograph: proteins: notice variable size, dark patches within the lysosomes are debris being digested. Destruction of organelles, and their replacement lysosome fuses with er-derived autophagic vacuole autophagolysosome contents enzymatically digested residual body: either released (exocytosis) or retained lipofuscin granules. Age of a cell can be estimated based on how many lipofuscin granules are visible: degradation of internalized material.

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