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Lecture

BIOL*1090 Notes - Cytoskeleton

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Department
Biology
Course
BIOL 1090
Professor
Marc Coppolino
Semester
Fall

Description
BIOLOGYThe Cytoskeletoncytoskeleton dynamic network of interconnected filaments and tubules that extends throughout the cytosol and some organelles or eukaryotesA Functionstructural support o actin filaments intermediate filaments microtubulesspatial organization within the cell o microtubules o organelles do not just float around they associate with the cytoskeletonintracellular support o microtubulescontractility and motility o actin filamentsmotor proteins are most closely associated with microtubules and actin filaments as intermediate filaments are not generally a part of the vesicular transport processMicrotubules Overviewlargest cytoskeletal element 25nm diameterpolymer of proteins tubulin and tubulintwo major types o axonemal microtubuleshighly organized stablemight form permanent part of the cell part of structures axoneme involved in cell movement example flagella cilia o cytoplasmic microtubulesloosely organized very dynamiclocated within the cell in the cytosolA Structure andheterodimers form long protofilamentsheterodimers aligned in same direction head to tail o creates polarityMTs have fastgrowing plus end and slowgrowing minus endstructural polarity is important for MT growthshrinkage and direction of movement of material along MT 13 protfilaments form a longitudinal array o hollow cylinderheterodifferentdimertwo
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