BIOL 3010 Lecture Notes - Apoptosis, Commissure, White Matter

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Outline of lecture 10: regionalization of neural epithelium, from neural plate to neural tube. Rehash of previous lectures (neural plate, retinoic acid, hox, shh, notochord, floor plate, neural tube) Neural tube defects (e. g. spina bifida) associated with folic acid deficiency: regional structure of neural tube. A to p structures: telencephalon (ant. forebrain), diencephalons (post. forebrain), mesencephalon (midbrain), rhombencephalon (hindbrain), spinal cord (see fates on p. 3) D to v structures: alar plate (dorsal, sensory info) and basal plate (ventral, motor/hormonal control nerves) These features combine: spinal cord and brain have alar and basal divisions pial. Neural tube is a single layer of epithelium; lumen = ventricular, outer = Neural precursor cell s nucleus moves up and down during cell cycle; division gives rise to neurons and glial cells. Cerebral cortex develops by waves of cells that migrate from ventricular. Lissencephaly develops if lis1 or dcx genes involved in migration are.

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