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BIOL 3010 (47)

16 Vasculogenesis

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BIOL 3010
Scott Schau

Outline of Lecture 16 Vasculogenesis, Angiogenesis, Hematopoiesis I. Vasculogenesis and Angiogenesis A) Vasculogenesis - Refers to the initial formation of blood vessel in fetus - Splanchnic mesoderm gives rise to angioblasts, which forms blood vessels - In yolk sac, this involves blood islands; in embryo, involves endothelial cords - Cords coalesce to become primary endothelial plexus B) Angiogenesis - Refers to remodeling of vasculature, throughout life - Occurs through sprouting, branching, and vascular pruning C) Molecules involved in blood vessel formation - FGF is involved in angioblast formation from paraxial and lateral plate mesoderm - VEGF is expressed by endoderm, and receptors are on angioblasts - TIE1 and TIE2 are receptor tyrosine kinases on endothelial cells that involved in recruitment of mesenchymal cells to form smooth muscle layer II. Hematopoiesis A) Prenatal hematopoiesis occurs in three stages 1) Mesoblastic stage: hematopoietic stem cells develop in blood islands of the yolk sac and chorion 2) Hepatic (visceral) stage: hematopoiesis takes place primarily in liver 3) Myeloid stage: hematopoiesis takes place in bone marrow - Definitive hema. pluripotent stem cells
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