BIOL 3010 Lecture Notes - Interleukin 3, Monocyte, Cd90

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29 Jan 2013
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Vasculogenesis, Angiogenesis, Hematopoesis
Vasculogenesis – de novo formation of blood vessels during fetal life
3 stages:
1) embryonic splanchnic mesoderm mesenchyme angioblasts
angioblasts fuse to form ENDOTHELIAL CORDS
differentiation involves VEGF expression by endoderm
(extra-embryonic splanchnic mesoderm also forms HSC’s)
2) angioblasts in cords endothelium (also requires VEGF)
lumen forms
3) cords coalesce in yolk sac and embryo primary endothelial plexus
Angiogenesis – can continue throughout life to meet metabolic needs
sprouting, branching, pruning
supporting cells: smooth muscle and pericytes
recruitment –
mesenchyme secretes angiopoietin-1
endothelium binds APO via TIE receptors
activated endothelium secretes PDGF recruits cells
activated endothelium secretes TGF-B stops prolif. and
induces supporting cell diff.
occurs in embryo for mature vasculature (TIE2 for capillary sprouting)
later for wound healing and tumor growth
angioblasts
endothelial cords
VEGF
primary endothelial
plexus
angiopoietin
TIE receptors
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