BIOM 3090 Lecture Notes - Lecture 12: Parasympathomimetic Drug, Acetylcholine Receptor, Nicotinic Acetylcholine Receptor
8 Feb 2019
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Esters of choline: a. acetylcholine, b. bethanechol, not absorbed/distributed well, 2. Organ system effects muscarinic activation: pilocarpine is used to treat glaucoma (increase intraocular pressure). What affect will it have in the eye: if it gets into the systemic circulation what effect will it have in the, heart, blood vessels, bronchi. Toxicities associated with cholinomimetics: muscarinic agonists, mushrooms: genus inocybe contain high levels of muscarine, pilocarpine overdose, ingestion -> symptoms of muscarinic excess, activation of muscarinic receptors in, 1. Sweat glands + blood vessels (edrf: 3. Symptoms of muscarinic excess: diarrhea, urination, miosis, bradycardia, bronchoconstriction, excitiation (cns, lacrimatoin, sweating and salivation, symptoms of muscarinic excess = extention of effect of activating muscarinic receptors. Ganglionic blockers: trimethaphan, can be used for hypertensive crisis or dissecting aortic aneurysm - rarely used clinically, only if other drugs ineffective or contraindicated, 2. Neuromuscular blockers: d-tubocurarine, used in surgical procedures to reduce skeletal muscle contraction.
