BIOM 3090 Lecture Notes - Lecture 5: Sildenafil, Enalapril, Vascular Smooth Muscle

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Beta 1 and beta 2 are the two main subtypes of adrenergic receptors. Alpha 1 and alpha 2, which can be further sub classified as alpha 1a/b/c etc. When we classify drugs we group them as specific agonists (act on only one type of receptor eg beta 1) or mixed agonists (act on multiple types of receptors) The ligand can either be an agonist or an antagonist. B receptors are all g proteins and act primarily by the second messenger cyclic amp. When the receptor is activated, the g protein is activated, which activated cyclic amp, which acts on downstream molecules usually pka. When these become out of control, there are problems with growth etc. When a ligand binds to this type of receptor, there is a conformational change that occurs on the cytosolic domain. The tm domain often dimerizes when a ligand binds and can be either heterogenous or homogenous.

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