BIOM 4180 Lecture Notes - Lecture 13: Hypokalemia, Fibrosis, Myopathy
14 Aug 2018
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Increases intracellular ca+: adaptive phase: cellular hypertrophy helps increase contractility, maladaptive phase: massive cellular hypertrophy and hypoxia, apoptosis, decreases contractility, ca++ transient less and slower movement of ca++ into the cell from the sr. Due to inefficient pumps back to sr: microdomains of ca+, yeah, the average [ca++] might be fine. Serca normally puts ca++ back into sr, but it"s expression and activity is less in people with heart failure. Protein phosphatase 2a activity goes up: 2. Pka +pi on plb and inhibitor 1: target one thing to promote serca activity, prevents inhibitory pathway too. What is going on, so much variation: you can"t just say heart failure and non-heart failure, comorbidities (hypertension, diabetes), age, sex, cause of death, random catecholamine surge, not all heart failures are equal! So many different myopathies: tissue handling, time of collection, isolation procedure (temperature, speed), site of collection, not unaltered, it is unclear, heart failure treatment, complex, depends on etiology, comorbidities, 1.
