BIOM 4180 Lecture Notes - Lecture 14: Skeletal Muscle, Echocardiography, Ranolazine
14 Aug 2018
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Document Summary
Myocardial ischaemia, a reduction in blood supply to the heart, or an increased demand for blood supply that is not met. Not enough nutrients, and waste products not taken away: decreased supply from a coronary occlusion. Increased demand in intense exercise: 2 types, angina pectoris (transient), no permanent muscle damage/death, myocardial infarction, causes permanent damage via cell necrosis, angina, deep poorly localized discomfort in the chest or arm, 1. Occurs at rest and lasts for more than 20 min: 2. Crescendo (each time is worse than the last: unstable refers to sudden onset without obvious trigger, caused by thrombus/plaque rupture, infection, 3. Na+ channels opening at inappropriate times, prolong ap, long qt syndrome: ex. Ankyrin mutation disrupts how ncx works: 2. Ncx will turn on, then too much ca++ in the cell. Patient history: symptoms of chest pain, hosrtness of breath, excecssive sweating, nausea, vomiting: 2.
