HK 3100 Lecture Notes - Lecture 16: Ampa Receptor, Tachykinin Receptor 1, Frequency Response

• School: University of Guelph
• Department: Human Kinetics
• Course: HK 3100
• Professor: leahbent

Document Summary

Increased responsiveness of a neuron to a normal input: recruitment of a response to subthreshold input stimulus, occurs peripherally and centrally. Increased frequency response and it continues longer: lost information/modified information. Pre-emptive analegsia: goal: reduce sensitization, prevent development of chronic pain, analegesic treatment before surgical procedure. Increase sensitivity telling you to pull away and protect yourself: but this can also go really out of whack. Induce injury (sensitize), the graph slides to the left. In the blue section any stimulus that was painful is now extremely painful (this is hyperalgesia) In the red area these stimuli were subthreshold have now increased (allodynia: something that wasn"t painful is now painful. Neurogenic inflammation: an important sequela to central sensitization, an inflammatory process not due to an infection, neurogenic because it is due to the nerve; it is caused by the nerve through the sensitization. Clinical manifestation of central sensitization: increased receptive field size.