Class Notes (835,288)
Canada (509,068)
HK 2810 (29)
Lecture

1. Communication Principles (full doc.).pdf

36 Pages
138 Views
Unlock Document

Department
Human Kinetics
Course
HK 2810
Professor
Coral Murrant
Semester
Fall

Description
List of common acronyms AI - angiotensin I EC - endothelial cell AII - angiotensin II EDCF - endothelial derived contracting factor aa - amino acids EDHF - endothelial derived hyperpolerizing factor AC - adenylate cyclase EDP - end diastolic pressure ACE - angiotensin converting enzyme EDRF - endothelial derived relaxing factor ACh - acetylcholine EDV - end diastolic volume ACTH - adrenocorticotrophic hormone Eion - equilibrium potential for an ion ADH (-VP) - antidiruetic hormone EpDRF - epithelial derived relaxing factor (a.k.a vasopressin) Epi - epinepherine ADP - adenosine diphosphate EPSP - excitatory post synaptic potential ADO - adenosine ERP - effective refractory period ALDO - aldosterone ERV - expiratory reserve volume AMP - adenosine monophosphate ESV - end systolic volume AMPA - ▯amino-3-hydroxy-5methyl-4- ET-1 - endothelin-1 isoxazol propionic acid ANP - atrial naturetic peptide FFA- free fatty acids ANS - autonomic nervous system FRC - function residual capacity AP - action potential FSH - follicle stimulating hormone ATP - adenosine triphosphate AV - atrioventricular GABA- gamma amino butyric acid GC - guanylate cyclase BB - buffer base GDP - guanosine diphosphate BC - Bowmans capsule GFR - glomerular filtration rate BK - bradykinin GH - growth hormone GHRH - growth hormone releasing hormone CA- carbonic anhydrase Glu - glucose Ca ++-calciumions GnRH - gonadotropin releasing hormone cAMP - cyclic adenosine monophosphate GTO - golgi tendon organ CCK - cholecyctokinin GTP - guanosine triphosphate CD - collecting duct CFC - capillary filtration coefficient H - hydrogen ion cG-P - cyclic guanosine monophosphate Hb - haemoglobin Cl -chlorideions hCG - human chorionic gonadotropin CNS - central nervous system HIS - histamine CO - cardiac output HR - heart rate CRH - corticotropin releasing hormone IC - inspiratory capacity DAG - diacyl glycerol IGF - insulin-like growth factor DT - distal tubule IPSP - inhibitory post synaptic potential IP -inosinetriphosphate 3 IRV - inspiratory reserve volume ISS - interstitial space 1. Communication - Principles 1 K+ - potassoim ions Q = flow LAP - left artial pressure r - radius LCST - lateral corticospinal tract R - resistance LGN - lateral geneculate nucleus R -arterialresistance a LH - luteinizing hormone RAP - right atrial pressure LofH - loop of Henle RBF - renal blood flow LS - lipid soluable Rc - receptor Rm - membrane receptor MAP - mean arterial pressure RRP - relative refractory period R v venous resistance MC - motor cortex RV - residual volume MCFP - mean circulatory filling pressure MLCK - myosin light chain kinase SA- sinoatrial MSFP- mean systemic filling pressure SC - superior colliculus SER - smooth endoplasmic reticulum + Na - sodium ions SI - small intestine NE - norepinepherine SNS - sympathetic nervous system NLS - non lipid soluable SR - sarcoplasmic reticulum NMDA- N-methyl-D-aspartate SV - stroke volume NO - nitric oxide NOS - nitric oxide synthase TLC - total lung capacity T mtransportmaximum P - pressure TRH - thyropropin releasing hormone Pa-arterialpressure TRP - total peripheral resistance P -alveolarpressure TSH - thyroid stimulating hormone A Patm -atmosphericpressure Pc - capillary hydrostatic pressure VA-alveolarventilation Pi - inorganic phosphate VC - vasoconstriction PK-A- protein kinase A VDil - vasodilation PK-G - protein kinase G V DS - dead space volume PLC - phospholipase C V E- ventilation P -lymphhydrostaticpressure VIP - vasoactive intestinal peptide lymph Pm-mitochondrialpressure VLDL - very low density lipoproteins PNS - parasympathetic nervous system V m -membranepotential P - pleural pressure VR - venous return pl PRF - prolactin releasing factor VSM - vascular smooth muscle Pt-tissuehydrostaticpressure V Ttidalvolume PT- transmural pressure PTC - peritubular capillary 5HT - 5-hydroxy tryptomine PTH - parathyroid hormone Pv- venous pressure ▯c - capillary osmotic pressure ▯t - tissue osmotic pressure 1. Communication - Principles 2 A. Transport across membranes - endocytosis 1. pinocytosis 2. phagocytosis 3. Receptor mediated endocytosis B. Transport through membranes 1. Communication - Principles 3 How is movement through the membrane achieved? 1. Diffusion What drives diffusion: A) concentration gradients B) electrical gradients 2. Protein channels A) show specificity B) # and types of channels not fixed per cell C) subtypes i) voltage dependent channel ii) ligand dependent channel 1. Communication - Principles 4 3. Protein mediated transport A) facilitated transport General characteristics of protein mediated transport i) can be saturated ii) shows specificity iii) shows inhibition a) competitive inhibition b) non-competitive inhibition 1. Communication - Principles 5 B)Active transport 1. primary active transport 2. Secondary active transport 1. Communication - Principles 6 Movement between compartments and cell asymmetry extracellular P ATP ADP intracellular Na+ Lumen of Lumen of intestine Glu blood Na+ aa K+ vessel aa Na+ Na+ Glu Blood flow Glu Glu Na+ K+ fructose fructose 1. Communication - Principles 7 A B Two containers separated by a permiable membrane, different 0.1M 0.01M concentrations of KCl on either side of KCl KCl the membrane. How will the ions move. A B 0.1 K+ 0.01K + Force governing movement of ions is concentration gradient : flow from high concentration to low concentration. 0.1 Cl- 0.01 Cl- A B What if membrane were semipermiable?, not permiable to Cl? 0.1 K+ 0.01K+ 0.1 Cl 0.01 Cl 1. Communication - Principles 8 Nernst Equation: RT ln [X] A zF(E -EA) =B0 [X]B -61mV log [X] A OR (EA-E B = z [X]B 1. Communication - Principle9 What electrical gradient do I need to A B oppose this chemical gradient? + 0.1 K 0.01 (EA-EB) = -61mV log [XA K + z [X]B -61mV log [0.1] (EA-EB) = +1 [0.01] Eion = -61mV A B Therefore if the difference between EAand E B -61 mV there will be 0.1 K+ 0.01 no net K+ movement. + K -61 0 1. Communication - Principles 10 A B If EA–E Bs actually –80mV (more negative that Eion) – net movement from 0.1 K+ 0.01 B toA. + K -80 A B If EA–E B -40 mV (more positive than Eion) – the net movement would be fromAto B. 0.1 0.01 K+ K+ -40 A B If E –E is +60 (more positive than A B Eion) – net movement fromAto B. K+ will move down its electrical and 0.1 0.01 chemical gradient. K+ K+ +60 1. Communication - Principles 11 Concentration in Concentration in Equilibrium potential Relative Ion intracellular fluid extracellular fluid (Eion) permeability Na + 9.2 mM 120 mM +68 mV 1 K + 140 mM 2.5 mM -106 mV 100 - Cl 3 mM 120 mM -97 mV 200 ++ Ca 0.0001 mM 2.4 mM +133 mV 0 A B Intracellular Extracellular compartment compartment + + 9.2 mM Na 120 mM Na + + 140 mM K 2.5 mM K 3 mM Cl - 120 mM Cl - 0.0001 Ca++ 2.4 mM Ca ++ Goldman equation: CNa+ ina + CK+ Pin+ CCl-outPCl + Ca++ ina++ Vm = -61 log CNa+ PNa + CK+ PK + CCl- PCl + Ca++ PCa++ out out in out 1. Communication - Principles 12 A B Equilibrium potential Relative Intracellular Extracellular compartment compartment (Eion) permeability 9.2 mM Na + 120 mM Na + +68 mV 1 140 mM K + 2.5 mM K + -106 mV 100 - - 3 mM Cl 120 mM Cl -97 mV 200 0.0001 Ca++ 2.4 mM Ca ++ +133 mV 0 1. Communication - Principles 13 CHARACTERISTICS OF THE RESTING MEMBRANE POTENTIAL The following problems address some of the fundamental concepts to be considered in the explanation of the resting membrane potential. The problems involve solutions to the Nernst equation and the Goldman equation, given different concentrations of ions and diff
More Less

Related notes for HK 2810

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit