MBG 1000 Lecture 11: SICKLE CELL ANEMIA FEB 0117

• School: University of Guelph
• Department: Molecular Biology and Genetics
• Course: MBG 1000
• Professor: Georgevander Merwe

Document Summary

Autosomal recessive diseases: sickle cell anemia: phenotype first described by physician james herrick, 1910 chicago. Symptoms: chronic fatigue, shortness of breath, paleness, pain. Infections: enlarged spleen, sores that don"t heal, stroke, eye problems. Sickle cell anemia (sca: anemia: decreased capacity to deliver oxygen to tissue; brought on by, decreased rbc number or rbc volume, rbcs deficient in hemoglobin. Treatment for sickle cell anemia: antibiotics taken daily, pain management, prevention of complications, blood transfusions. Origin and frequency of sickle cell anemia: origin, sub-saharan africa; mediterranean countries (turkey, greece, italy); south/central america; Frequency: west/central africa, 45% of people are carriers, 1-2% of babies are born with sca. In the usa: 1 in 500 african american are born with sca, 1 in 12 african americans are carriers of sca, 1 in 36 000 hispanic americans are born with sca. Malaria: malaria, blood related disease, 300-500 million cases per year ww, 1. 5-2. 7 million deaths per year ww.