MCB 2050 Lecture Notes - Lecture 7: Dynamin, Lysosome, Clathrin
3 Apr 2017
School
Department
Course
Professor
Document Summary
Digests/degrades all types of macromolecules, even organelles (e. g. autophagy, mitophagy) Only active at low ph of 4. 6 in the lysosomal lumen. Inner leaflet of the lysosome is lined with proteins that are heavily glycosylated to prevent degradation from those enzymes. Not active in er, golgi, cytosol, since the ph is neutral. Products of degradation transported to the cytosol to be reused. A membrane-bound atpase proton pump pumps h+ from the cytosol into the. High dynamic, takes on all shapes and sized, comes and goes as needed by the cell lysosome to maintain low ph. Lysosomal proteins are n-glycosylated in rer, transported to golgi to be modified. For proteins that work in lysosome, not to be degraded. The lumenal side recognizes and binds lysosomal proteins containing. This binding likely changes the conformation on the cytosolic side: gga adaptor has multiple binding domains, it also binds clathrin a)
