MCB 2050 Lecture Notes - Lecture 12: Cyclin E, S Phase, Growth Factor

• School: University of Guelph
• Department: Molecular and Cellular Biology
• Course: MCB 2050
• Professor: ALL

Document Summary

Multi-step carcinogenesis: you"ll have alteration or inactivation in tumour suppressor genes and increase proliferation rate. Immiortaliation requires overexpression of telomerase to maintain telomere length: (v) they must be able to sustain angiogenesis to provide an adequate supply of oxygen and nutrients (upregulate expression of vascular endothelial growth factor. Tumors arise through a process of clonal evolution driven by mutations. Review topic 5. 2 oncogenes: oncogenes: promote cell proliferation or survival. Her2 is a member of the epidermal growth factor receptor (egfr) family. Reciprocal translocation between chromosomes 8 and 14 places c-myc gene under the control of a strong immunoglobulin gene enhancer resulting in overproduction of c-myc protein in. Review topic 5. 3 tumor suppressor genes: tumor suppressor genes inhibit cell proliferation or survival. Arise by deletion, point mutation or promoter methylation causing a loss-offunction mutation: the retinoblastoma protein rb acts as a brake on the cell cycle by inhibiting the activity of the transcription factor e2f.